Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro

RNA interference (RNAi) by small interfering RNAs (siRNAs) is a promising therapeutic approach. Because siRNA has limited intracellular access and is rapidly cleared in vivo, the success of RNAi depends on efficient delivery technologies. Particularly, polyion complexation between block catiomers an...

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Bibliographic Details
Main Authors: Wenqian Yang, Takuya Miyazaki, Pengwen Chen, Taehun Hong, Mitsuru Naito, Yuji Miyahara, Akira Matsumoto, Kazunori Kataoka, Kanjiro Miyata, Horacio Cabral
Format: Article
Language:English
Published: Taylor & Francis Group 2021-09-01
Series:Science and Technology of Advanced Materials
Subjects:
Online Access:http://dx.doi.org/10.1080/14686996.2021.1976055