BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural da...

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Bibliographic Details
Main Authors: Thomas Seeholzer, Susanne Kurz, Florian Schlauderer, Simone Woods, Torben Gehring, Simon Widmann, Katja Lammens, Daniel Krappmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
lymphocyte signaling
CARMA1–BCL10–MALT1 (CBM) signalosome complex
CARD11
NF- kappa B
MALT1 paracaspase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02695/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02695/full

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