Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat

Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat

Nicotine is acknowledged as the key addictive compound of tobacco. Varenicline (Champix® or Chantix®), mainly acting as a partial agonist at the α4β2 nicotinic receptor, is an approved smoking cessation pharmacotherapy, although with efficacy limited to a portion of smokers. Smokers differ in the mo...

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Bibliographic Details
Main Authors: Vernon Garcia-Rivas, Jean-François Fiancette, Nazzareno Cannella, Maria Carbo-Gas, Prisca Renault, Jessica Tostain, Véronique Deroche-Gamonet
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
intravenous self-administration
nicotine
cues
individual differences
varenicline
rat
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00159/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2019.00159/full

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