Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy

Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy

Abstract The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes is expressed through changes in gene transcription ca...

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Bibliographic Details
Main Authors: Jan Haas, Stefan Mester, Alan Lai, Karen S Frese, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Tobias Rausch, Rouven Nietsch, Jes‐Niels Boeckel, Avisha Carstensen, Mirko Völkers, Carsten Dietrich, Dietmar Pils, Ali Amr, Daniel B Holzer, Diana Martins Bordalo, Daniel Oehler, Tanja Weis, Derliz Mereles, Sebastian Buss, Eva Riechert, Emil Wirsz, Maximilian Wuerstle, Jan O Korbel, Andreas Keller, Hugo A Katus, Andreas E Posch, Benjamin Meder
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:EMBO Molecular Medicine
Subjects:
cardiac transcriptome
dilated cardiomyopathy
expression quantitative trait locus
genomic structural variation
heart failure
Online Access:https://doi.org/10.15252/emmm.201707838

Internet

https://doi.org/10.15252/emmm.201707838

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