GB Virus C E2 Inhibits PD-1-Mediated T Cell Signaling Dysfunction during Chronic Viral Infection

GB Virus C E2 Inhibits PD-1-Mediated T Cell Signaling Dysfunction during Chronic Viral Infection

Background: Program death receptor 1 (PD-1) is a co-inhibitory receptor that is upregulated and contributes to T cell dysfunction (exhaustion) during chronic viral infections, including HIV and HCV. GB virus C (GBV-C) is a persistent human virus, and co-infection is associated with reduced immune ac...

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Bibliographic Details
Main Authors: Nirjal Bhattarai, Jennifer L. Welch, Jinhua Xiang, Muthu Saravanan Manoharan, Jeffrey A. Martinson, Alan L. Landay, Sunil K. Ahuja, James H. McLinden, Jack T. Stapleton
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Proceedings
Subjects:
GBV-C
PD-1
T cell exhaustion
HIV
Online Access:https://www.mdpi.com/2504-3900/50/1/62

Internet

https://www.mdpi.com/2504-3900/50/1/62

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