Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy

Evolving Roles for Targeting CTLA-4 in Cancer Immunotherapy

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a membrane glycoprotein expressed by activated effector T cells (Teffs) and participates in the repression of T cell proliferation, cell cycle progression and cytokine production. Currently, antibodies targeting CTLA-4, ipilimumab and tremelimu...

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Bibliographic Details
Main Authors: Yinghao Zhao, Wei Yang, Yuanyuan Huang, Ranji Cui, Xiangyan Li, Bingjin Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ctla-4
PD-1
Antibody
ipilimumab
Tremelimumab
Online Access:https://www.karger.com/Article/FullText/490025

Internet

https://www.karger.com/Article/FullText/490025

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