Detecting amino acid preference shifts with codon-level mutation-selection mixture models

Detecting amino acid preference shifts with codon-level mutation-selection mixture models

Abstract Background In recent years, increasing attention has been placed on the development of phylogeny-based statistical methodologies for uncovering site-specific changes in amino acid fitness profiles over time. The few available random-effects approaches, modelling across-site variation in ami...

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Bibliographic Details
Main Authors: S. Omar Kazmi, Nicolas Rodrigue
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Evolutionary Biology
Subjects:
Substitution models
Monte Carlo methods
Mixture models
Online Access:http://link.springer.com/article/10.1186/s12862-019-1358-7

Internet

http://link.springer.com/article/10.1186/s12862-019-1358-7

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