Drp1‐dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia

Abstract Friedreich ataxia is an autosomal recessive, neurodegenerative disease characterized by the deficiency of the iron‐sulfur cluster assembly protein frataxin. Loss of this protein impairs mitochondrial function. Mitochondria alter their morphology in response to various stresses; however, suc...

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Bibliographic Details
Main Authors: Joseph Johnson, Elizabeth Mercado‐Ayón, Elisia Clark, David Lynch, Hong Lin
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Pharmacology Research & Perspectives
Subjects:
ATP
Online Access:https://doi.org/10.1002/prp2.755