Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Summary: Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by th...

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Bibliographic Details
Main Authors: Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G. Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M.T. Burgering
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
NMR spectroscopy
structural biology
intrinsically disordered proteins
post-translational modification
phosphorylation
Wnt signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008639

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http://www.sciencedirect.com/science/article/pii/S2211124721008639

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