Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1<i>H</i>)-pyrazoles

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1<i>H</i>)-pyrazoles

New <i>N</i>-acetyl/<i>N</i>-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral compounds were separated into their single enan...

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Bibliographic Details
Main Authors: Paolo Guglielmi, Simone Carradori, Giulio Poli, Daniela Secci, Roberto Cirilli, Giulia Rotondi, Paola Chimenti, Anél Petzer, Jacobus P. Petzer
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
pyrazoline
monoamine oxidase
enantioseparation
molecular modelling
prenyl
Online Access:https://www.mdpi.com/1420-3049/24/3/484

Internet

https://www.mdpi.com/1420-3049/24/3/484

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