Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats

Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats

Loss-of-function PTEN Induced Kinase 1 (PINK1) mutations cause early-onset familial Parkinson's disease (PD) with similar clinical and neuropathological characteristics as idiopathic PD. While Pink1 knockout (KO) rats have mitochondrial dysfunction, locomotor deficits, and α-synuclein aggregate...

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Bibliographic Details
Main Authors: Rose B. Creed, Rosalinda C. Roberts, Charlene B. Farmer, Lori L. McMahon, Matthew S. Goldberg
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Neurobiology of Disease
Subjects:
Dorsal striatum
PINK1
Parkinson's disease
Excitatory transmission
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120305222

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http://www.sciencedirect.com/science/article/pii/S0969996120305222

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