Safety evaluation of the excessive intake of Bacillus subtilis C-3102 in healthy Japanese adults: A randomized, placebo-controlled, double-blind, parallel-group, comparison trial

Objective: Continuous intake of Bacillus subtilis C-3102 (B. subtilis C-3102) has been reported to modulate the gut microbiota and increase the bone mineral density of the femur in healthy adults. This study aimed to evaluate the safety of excessive B. subtilis C-3102 intake through a randomized, pl...

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Bibliographic Details
Main Authors: Misaki Hatanaka, Hiroki Kanzato, Ryoko Tsuda, Isao Nadaoka, Masaaki Yasue, Tomohiro Hoshino, Shin-ichiro Iio, Tsuyoshi Takara
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750018307601