Apolipoprotein M Inhibits Angiogenic and Inflammatory Response by Sphingosine 1-Phosphate on Retinal Pigment Epithelium Cells

Apolipoprotein M Inhibits Angiogenic and Inflammatory Response by Sphingosine 1-Phosphate on Retinal Pigment Epithelium Cells

Sphingosine 1-phosphate (S1P) is a potent lipid mediator that modulates inflammatory responses and proangiogenic factors. It has been suggested that S1P upregulates choroidal neovascularization (CNV) and may be deeply involved in the pathogenesis of exudative age-related macular degeneration (AMD)....

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Bibliographic Details
Main Authors: Ryo Terao, Megumi Honjo, Makoto Aihara
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine 1-phosphate
sphingolipids and inflammation
S1P-receptors
apolipoprotein M
high-density lipoprotein
choroidal neovascularization
age-related macular degeneration
vascular endothelial growth factor
hypoxia inducible factor
interleukin-8
Online Access:https://www.mdpi.com/1422-0067/19/1/112

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https://www.mdpi.com/1422-0067/19/1/112

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