Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson’s Disease: A Network Pharmacological Approach

Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson’s Disease: A Network Pharmacological Approach

Background. Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, which currently lacks disease-modifying therapy to slow down its progression. Idebenone, a coenzyme Q10 (CQ10) analogue, is a well-known antioxidant and has been used to treat neurological disorders....

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Main Authors: Pei Kun He, Yu Yuan Gao, Feng-Juan Lyu, Jia Ning Chen, Yu Hu Zhang, Kun Nie, Qing Xi Zhang, Rui Huang, Qing Rui Duan, Man Li Guo, Zhi Hua Liu, He Ling Huang, Gui Xian Ma, Li Juan Wang, Li Min Wang
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2021/8548380

Internet

http://dx.doi.org/10.1155/2021/8548380

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