Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.

Dengue is a mosquito-borne viral infection that has spread globally in recent years. Around half of the world's population, especially in the tropics and subtropics, is at risk of infection. Every year, 50-100 million clinical cases are reported, and more than 500,000 patients develop the sympt...

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Bibliographic Details
Main Authors: Hideaki Shimizu, Akatsuki Saito, Junko Mikuni, Emi E Nakayama, Hiroo Koyama, Teruki Honma, Mikako Shirouzu, Shun-Ichi Sekine, Tatsuo Shioda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-11-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007894