AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.

AMP protein kinase (AMPK) plays an important role in food intake and energy metabolism, which are synchronized to the light-dark cycle. In vitro, AMPK affects the circadian rhythm by regulating at least two clock components, CKIα and CRY1, via direct phosphorylation. However, it is not known whether...

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Bibliographic Details
Main Authors: Jee-Hyun Um, Julie S Pendergast, Danielle A Springer, Marc Foretz, Benoit Viollet, Alexandra Brown, Myung K Kim, Shin Yamazaki, Jay H Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3069094?pdf=render