Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Summary: Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segment length in CA1 of the Fmr1−/y mouse hippocampus,...

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Bibliographic Details
Main Authors: Sam A. Booker, Laura Simões de Oliveira, Natasha J. Anstey, Zrinko Kozic, Owen R. Dando, Adam D. Jackson, Paul S. Baxter, Lori L. Isom, Diane L. Sherman, Giles E. Hardingham, Peter J. Brophy, David J.A. Wyllie, Peter C. Kind
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
fragile X syndrome
ASD/ID
axon initial segment
hyperexcitability
homeostasis
structural plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309736

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http://www.sciencedirect.com/science/article/pii/S2211124720309736

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