Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication.

Japanese encephalitis virus (JEV) is a major cause of viral encephalitis in South and South-East Asia. Lack of antivirals and non-availability of affordable vaccines in these endemic areas are a major setback in combating JEV and other closely related viruses such as West Nile virus and dengue virus...

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Main Authors: V Haridas, Kullampalayam Shanmugam Rajgokul, Sandhya Sadanandan, Tanvi Agrawal, Vats Sharvani, M V S Gopalakrishna, M B Bijesh, Kanhaiya Lal Kumawat, Anirban Basu, Guruprasad R Medigeshi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3547849?pdf=render