TOP2B: The First Thirty Years

Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is re...

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Main Authors:	Caroline A. Austin, Ka C. Lee, Rebecca L. Swan, Mushtaq M. Khazeem, Catriona M. Manville, Peter Cridland, Achim Treumann, Andrew Porter, Nick J. Morris, Ian G. Cowell
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	International Journal of Molecular Sciences
Subjects:	Topoisomerase II TOP2 Cell cycle cell biology transcription review
Online Access:	http://www.mdpi.com/1422-0067/19/9/2765

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spelling	doaj-43cafe61a92848e69a996229b779a5d12020-11-25T00:47:07ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-09-01199276510.3390/ijms19092765ijms19092765TOP2B: The First Thirty YearsCaroline A. Austin0Ka C. Lee1Rebecca L. Swan2Mushtaq M. Khazeem3Catriona M. Manville4Peter Cridland5Achim Treumann6Andrew Porter7Nick J. Morris8Ian G. Cowell9Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKNUPPA, Newcastle University, Newcastle upon Tyne NE2 4HH, UKNUPPA, Newcastle University, Newcastle upon Tyne NE2 4HH, UKSchool of Biomedical Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKInstitute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UKType II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery.http://www.mdpi.com/1422-0067/19/9/2765Topoisomerase IITOP2Cell cyclecell biologytranscriptionreview
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Caroline A. Austin Ka C. Lee Rebecca L. Swan Mushtaq M. Khazeem Catriona M. Manville Peter Cridland Achim Treumann Andrew Porter Nick J. Morris Ian G. Cowell
spellingShingle	Caroline A. Austin Ka C. Lee Rebecca L. Swan Mushtaq M. Khazeem Catriona M. Manville Peter Cridland Achim Treumann Andrew Porter Nick J. Morris Ian G. Cowell TOP2B: The First Thirty Years International Journal of Molecular Sciences Topoisomerase II TOP2 Cell cycle cell biology transcription review
author_facet	Caroline A. Austin Ka C. Lee Rebecca L. Swan Mushtaq M. Khazeem Catriona M. Manville Peter Cridland Achim Treumann Andrew Porter Nick J. Morris Ian G. Cowell
author_sort	Caroline A. Austin
title	TOP2B: The First Thirty Years
title_short	TOP2B: The First Thirty Years
title_full	TOP2B: The First Thirty Years
title_fullStr	TOP2B: The First Thirty Years
title_full_unstemmed	TOP2B: The First Thirty Years
title_sort	top2b: the first thirty years
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2018-09-01
description	Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery.
topic	Topoisomerase II TOP2 Cell cycle cell biology transcription review
url	http://www.mdpi.com/1422-0067/19/9/2765
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TOP2B: The First Thirty Years

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