IgE Trimers Drive SPE-7 Cytokinergic Activity

IgE Trimers Drive SPE-7 Cytokinergic Activity

Abstract Degranulation of mast cells and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells’ receptor-bound IgE antibodies. A widely used commercial monoclonal IgE antibody, SPE-7 IgE from Sigma, was found to possess the radi...

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Bibliographic Details
Main Authors: Heather J. Bax, Holly Bowen, Rebecca L. Beavil, Raymond Chung, Malcolm Ward, Anna M. Davies, Tihomir S. Dodev, James M. McDonnell, Andrew J. Beavil, Brian J. Sutton, Hannah J. Gould
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08212-6

Internet

https://doi.org/10.1038/s41598-017-08212-6

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