Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death

Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death

Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the enzyme, β(1,3)-D-glucan synthase. Loss of β(1...

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Bibliographic Details
Main Authors: Christopher Chin, Faith Donaghey, Katherine Helming, Morgan McCarthy, Stephen Rogers, Nicanor Austriaco
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-01-01
Series:Microbial Cell
Subjects:
caspofungin
AIF1
MCA1/YCA1
programmed cell death
Saccharomyces cerevisiae
Candida albicans
Online Access:http://microbialcell.com/researcharticles/deletion-of-aif1-but-not-of-yca1mca1-protects-saccharomyces-cerevisiae-and-candida-albicans-cells-from-caspofungin-induced-programmed-cell-death/

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http://microbialcell.com/researcharticles/deletion-of-aif1-but-not-of-yca1mca1-protects-saccharomyces-cerevisiae-and-candida-albicans-cells-from-caspofungin-induced-programmed-cell-death/

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