Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism

Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism

Abstract Background Distal arthrogryposis (DA) is a group of autosomal dominant skeletal muscle diseases characterized by congenital contractures of distal limb joints. The most common cause of DA is a mutation of the embryonic myosin heavy chain gene, MYH3. Human phenotypes of DA are divided into t...

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Bibliographic Details
Main Authors: Yiming Guo, William A. Kronert, Karen H. Hsu, Alice Huang, Floyd Sarsoza, Kaylyn M. Bell, Jennifer A. Suggs, Douglas M. Swank, Sanford I. Bernstein
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Skeletal Muscle
Subjects:
Distal arthrogryposis
Drosophila melanogaster
Myopathy
Myosin
Skeletal muscle
Online Access:http://link.springer.com/article/10.1186/s13395-020-00241-6

Internet

http://link.springer.com/article/10.1186/s13395-020-00241-6

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