Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of Chd7 from the Embryonic Mid-Hindbrain Region

Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of Chd7 from the Embryonic Mid-Hindbrain Region

Reduced fibroblast growth factor (FGF) signaling from the mid-hindbrain or isthmus organizer (IsO) during early embryonic development results in hypoplasia of the midbrain and cerebellar vermis. We previously reported evidence for reduced Fgf8 expression and FGF signaling in the mid-hindbrain region...

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Bibliographic Details
Main Authors: Alex P. A. Donovan, Tian Yu, Jacob Ellegood, Kimberley L. H. Riegman, Christa de Geus, Conny van Ravenswaaij-Arts, Cathy Fernandes, Jason P. Lerch, M. Albert Basson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Neuroanatomy
Subjects:
CHD7
mid-hindbrain
cerebellum
vermis
hypoplasia
Online Access:http://journal.frontiersin.org/article/10.3389/fnana.2017.00086/full

Internet

http://journal.frontiersin.org/article/10.3389/fnana.2017.00086/full

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