A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy

A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy

Immune checkpoint inhibitors have shown great potential in treating solid tumors, inducing durable remission and prolonged survival time in responders. Despite their promise, a large fraction of patients remains unresponsive to these treatments highlighting the need for biomarkers that can predict p...

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Bibliographic Details
Main Authors: Frederick S. Varn, Yue Wang, Chao Cheng
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:OncoImmunology
Subjects:
immunotherapy
genomics
tumor immunology
b cells
immune checkpoint blockade
gene signatures
biomarkers
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1513440

Internet

http://dx.doi.org/10.1080/2162402X.2018.1513440

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