Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and "BRCA-Like" Status, in Both Blood and Tumour DNA.

Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and "BRCA-Like" Status, in Both Blood and Tumour DNA.

Triple negative breast cancer is typically an aggressive and difficult to treat subtype. It is often associated with loss of function of the BRCA1 gene, either through mutation, loss of heterozygosity or methylation. This study aimed to measure methylation of the BRCA1 gene promoter at individual Cp...

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Bibliographic Details
Main Authors: Sarah L Daniels, George J Burghel, Philip Chambers, Shadi Al-Baba, Daniel D Connley, Ian W Brock, Helen E Cramp, Olena Dotsenko, Octavia Wilks, Lynda Wyld, Simon S Cross, Angela Cox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4963032?pdf=render

Internet

http://europepmc.org/articles/PMC4963032?pdf=render

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