Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart

In the adult heart, the epicardium becomes activated after injury, contributing to cardiac healing by secretion of paracrine factors. Here, we analyzed by single-cell RNA sequencing combined with RNA in situ hybridization and lineage tracing of Wilms tumor protein 1-positive (WT1+) cells, the cellul...

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Bibliographic Details
Main Authors: Julia Hesse, Christoph Owenier, Tobias Lautwein, Ria Zalfen, Jonas F Weber, Zhaoping Ding, Christina Alter, Alexander Lang, Maria Grandoch, Norbert Gerdes, Jens W Fischer, Gunnar W Klau, Christoph Dieterich, Karl Köhrer, Jürgen Schrader
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
myocardial infarction
epicardium
cardiac fibroblasts
ScRNAseq
transcriptomics
Online Access:https://elifesciences.org/articles/65921

Internet

https://elifesciences.org/articles/65921

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