Onset of Pup Locomotion Coincides with Loss of NR2C/D-mediated Cortico-striatal EPSCs and Dampening of Striatal Network Immature Activity

Onset of Pup Locomotion Coincides with Loss of NR2C/D-mediated Cortico-striatal EPSCs and Dampening of Striatal Network Immature Activity

Adult motor coordination requires strong coincident cortical excitatory input to hyperpolarized Medium Spiny Neurons (MSNs), the dominant neuronal population of the striatum. However, cortical and subcortical neurons generate during development large ongoing patterns required for activity-dependent...

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Bibliographic Details
Main Authors: Nathalie eDehorter, François J Michel, Thomas eMarissal, Yann eRotrou, Boris eMatrot, Catherine eLopez, Mark D Humphries, Constance eHammond
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Basal Ganglia
Locomotion
development
Striatum
patch clamp
immature activity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00024/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00024/full

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