Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates

2′-Deoxynucleoside conjugates of 13α-estrone were synthesized by applying the copper-catalyzed alkyne–azide click reaction (CuAAC). For the introduction of the azido group the 5′-position of the nucleosides and a propargyl ether functional group on the 3-hydroxy group of 13α-estrone were chosen. The...

Full description

Bibliographic Details
Main Authors: Brigitta Bodnár, Erzsébet Mernyák, János Wölfling, Gyula Schneider, Bianka Edina Herman, Mihály Szécsi, Izabella Sinka, István Zupkó, Zoltán Kupihár, Lajos Kovács
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
nucleosides
13α-estrone
copper-catalyzed alkyne–azide click reaction
triazoles
antiproliferative
17β-HSD1
Online Access:http://www.mdpi.com/1420-3049/21/9/1212

Internet

http://www.mdpi.com/1420-3049/21/9/1212

Similar Items