Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer

Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer

Despite progress in the treatment of pancreatic cancer, there is still a need for improved therapies. In this manuscript, we report clinical experience with a new therapy for the treatment of pancreatic cancer involving the implantation of encapsulated cells over-expressing a cytochrome P450 enzyme...

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Bibliographic Details
Main Authors: J. Matthias Löhr, Stephan L. Haas, Jens C. Kröger, Helmut M. Friess, Raimund Höft, Peter E. Goretzki, Christian Peschel, Markus Schweigert, Brian Salmons, Walter H. Gunzburg
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Pharmaceutics
Subjects:
pancreatic cancer
cytochrome P450
cell therapy
encapsulation
ifosfamide
safety
efficacy
bioencapsulation
targeting chemotherapy
low dose
quality of life
Online Access:http://www.mdpi.com/1999-4923/6/3/447

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http://www.mdpi.com/1999-4923/6/3/447

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