DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition.

DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition.

Group A Streptococcus (GAS) has developed a broad arsenal of virulence factors that serve to circumvent host defense mechanisms. The virulence factor DNase Sda1 of the hyperinvasive M1T1 GAS clone degrades DNA-based neutrophil extracellular traps allowing GAS to escape extracellular killing. TLR9 is...

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Bibliographic Details
Main Authors: Satoshi Uchiyama, Federica Andreoni, Reto A Schuepbach, Victor Nizet, Annelies S Zinkernagel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3375267?pdf=render

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http://europepmc.org/articles/PMC3375267?pdf=render

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