Limited importance of the dominant-negative effect of <it>TP53 </it>missense mutations

Limited importance of the dominant-negative effect of <it>TP53 </it>missense mutations

<p>Abstract</p> <p>Background</p> <p>Heterozygosity of <it>TP53 </it>missense mutations is related to the phenomenon of the dominant-negative effect (DNE). To estimate the importance of the DNE of <it>TP53 </it>mutations, we analysed the percenta...

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Bibliographic Details
Main Authors: Kordek Radzislaw, Jesionek-Kupnicka Dorota, Zawlik Izabela, Banaszczyk Mateusz, Hulas-Bigoszewska Krystyna, Bienkowski Michal, Piaskowski Sylwester, Szybka Malgorzata, Stoczynska-Fidelus Ewelina, Liberski Pawel P, Rieske Piotr
Format: Article
Language:English
Published: BMC 2011-06-01
Series:BMC Cancer
Subjects:
TP53
heterozygous mutation
dominant-negative effect
cancer cell lines
Online Access:http://www.biomedcentral.com/1471-2407/11/243

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http://www.biomedcentral.com/1471-2407/11/243

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