Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors

Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors

Deregulation of receptor tyrosine kinase (RTK)-signaling is frequently observed in many human malignancies, making activated RTKs the promising therapeutic targets. In particular, activated RTK-signaling has a strong impact on tumor resistance to various DNA damaging agents, e.g., ionizing radiation...

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Bibliographic Details
Main Authors: Boichuk Sergei, Dunaev Pavel, Galembikova Aigul, Bikinieva Firyuza, Nurgatina Ilmira, Mustafin Ilshat, Aukhadieva Aida, Kurtasanov Refat, Andriutsa Natalia, Shagimardanova Elena, Gorbunova Vera
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
gastrointestinal stromal tumor cells (gist)
imatinib mesylate (im)
resistance
fgfr-signaling
rad51 recombinase
homology-mediated dna repair
dna-topoisomerase ii inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/1/352

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https://www.mdpi.com/1422-0067/21/1/352

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