Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo

Two distinct conformers of PrPD type 1 of sporadic Creutzfeldt–Jakob disease with codon 129VV genotype faithfully propagate in vivo

Abstract Current classifications of sporadic Creutzfeldt–Jakob disease (sCJD) identify five subtypes associated with different disease phenotypes. Most of these histopathological phenotypes (histotypes) co-distribute with distinct pairings of methionine (M)/valine (V) genotypes at codon 129 of the p...

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Bibliographic Details
Main Authors: Ignazio Cali, Juan Carlos Espinosa, Satish K. Nemani, Alba Marin-Moreno, Manuel V. Camacho, Rabail Aslam, Tetsuyuki Kitamoto, Brian S. Appleby, Juan Maria Torres, Pierluigi Gambetti
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Acta Neuropathologica Communications
Subjects:
Prion protein
sCJDVV1
Prion strain
Histotype
Transmission properties
Lesion profile
Online Access:https://doi.org/10.1186/s40478-021-01132-7

Internet

https://doi.org/10.1186/s40478-021-01132-7

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