Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP prot...

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Main Authors:	Ju-Ha Kim, Jisung Hwang, Ji Hoon Jung, Hyo-Jung Lee, Dae Young Lee, Sung-Hoon Kim
Format:	Article
Language:	English
Published:	BMC 2019-12-01
Series:	Molecular Cancer
Subjects:	FOXP proteins Molecular networks Noncoding RNAs Cellular immunotherapy Clinical implications and cancer progression
Online Access:	https://doi.org/10.1186/s12943-019-1110-3

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spelling	doaj-4313b406b1374ff19900eb6d3f1d18092020-12-13T12:22:46ZengBMCMolecular Cancer1476-45982019-12-0118111910.1186/s12943-019-1110-3Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progressionJu-Ha Kim0Jisung Hwang1Ji Hoon Jung2Hyo-Jung Lee3Dae Young Lee4Sung-Hoon Kim5Cancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee universityCancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee universityCancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee universityCancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee universityDepartment of Herbal Crop Research, Rural Development Administration, National Institute of Horticultural and Herbal ScienceCancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee universityAbstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.https://doi.org/10.1186/s12943-019-1110-3FOXP proteinsMolecular networksNoncoding RNAsCellular immunotherapyClinical implications and cancer progression
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ju-Ha Kim Jisung Hwang Ji Hoon Jung Hyo-Jung Lee Dae Young Lee Sung-Hoon Kim
spellingShingle	Ju-Ha Kim Jisung Hwang Ji Hoon Jung Hyo-Jung Lee Dae Young Lee Sung-Hoon Kim Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression Molecular Cancer FOXP proteins Molecular networks Noncoding RNAs Cellular immunotherapy Clinical implications and cancer progression
author_facet	Ju-Ha Kim Jisung Hwang Ji Hoon Jung Hyo-Jung Lee Dae Young Lee Sung-Hoon Kim
author_sort	Ju-Ha Kim
title	Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_short	Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_full	Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_fullStr	Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_full_unstemmed	Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
title_sort	molecular networks of foxp family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
publisher	BMC
series	Molecular Cancer
issn	1476-4598
publishDate	2019-12-01
description	Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.
topic	FOXP proteins Molecular networks Noncoding RNAs Cellular immunotherapy Clinical implications and cancer progression
url	https://doi.org/10.1186/s12943-019-1110-3
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Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

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