Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP prot...

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Bibliographic Details
Main Authors: Ju-Ha Kim, Jisung Hwang, Ji Hoon Jung, Hyo-Jung Lee, Dae Young Lee, Sung-Hoon Kim
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Cancer
Subjects:
FOXP proteins
Molecular networks
Noncoding RNAs
Cellular immunotherapy
Clinical implications and cancer progression
Online Access:https://doi.org/10.1186/s12943-019-1110-3
Description
Summary:Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.
ISSN:1476-4598

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