Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with pharmacological agents named “correctors”. So far, a...

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Bibliographic Details
Main Authors: Virginia Spanò, Marilia Barreca, Vincenzo Cilibrasi, Michele Genovese, Mario Renda, Alessandra Montalbano, Luis Juan Vicente Galietta, Paola Barraja
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
cystic fibrosis
CFTR
F508del-CFTR
CFTR corrector
CFTR potentiator
Online Access:https://www.mdpi.com/1420-3049/26/5/1275

Internet

https://www.mdpi.com/1420-3049/26/5/1275

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