CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition

Summary: Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that is driven primarily by a transcriptional coactivator fusion composed of cyclic AMP-regulated transcriptional coactivator 1 (CRTC1) and mastermind-like 2 (MAML2). The mechanisms by which the chimeric CRTC1/MAML2...

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Bibliographic Details
Main Authors: Adele M. Musicant, Kshitij Parag-Sharma, Weida Gong, Monideepa Sengupta, Arindam Chatterjee, Erin C. Henry, Yi-Hsuan Tsai, Michele C. Hayward, Siddharth Sheth, Renee Betancourt, Trevor G. Hackman, Ricardo J. Padilla, Joel S. Parker, Jimena Giudice, Colin A. Flaveny, David N. Hayes, Antonio L. Amelio
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
cancer
chromosomal translocation
gene fusion
oncogene
CRTC1-MAML2
transcriptional co-activator
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000814

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http://www.sciencedirect.com/science/article/pii/S2211124721000814

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