Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure

Modeling the Function of TATA Box Binding Protein in Transcriptional Changes Induced by HIV-1 Tat in Innate Immune Cells and the Effect of Methamphetamine Exposure

Innate immune cells are targets of HIV-1 infection in the Central Nervous System (CNS), generating neurological deficits. Infected individuals with substance use disorders as co-morbidities, are more likely to have aggravated neurological disorders, higher CNS viral load and inflammation. Methamphet...

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Bibliographic Details
Main Authors: Ryan Tjitro, Lee A. Campbell, Liana Basova, Jessica Johnson, Julia A. Najera, Alexander Lindsey, Maria Cecilia Garibaldi Marcondes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
HIV
Tat
Methamphetamine
TATA-box
TATA-box binding peptide
Crispr/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03110/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03110/full

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