Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma

Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma

Chimeric antigen receptor (CAR)-engineered T cells represent a promising modality for treating glioblastoma. Recently, we demonstrated that CAR-T cells targeting carbonic anhydrase IX (CAIX), a protein involved in HIF-1a hypoxic signaling, is a promising CAR-T cell target in an intracranial murine g...

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Bibliographic Details
Main Authors: Jing Cui, Herui Wang, Rogelio Medina, Qi Zhang, Chen Xu, Iris H. Indig, Jingcheng Zhou, Qi Song, Pauline Dmitriev, Mitchell Y. Sun, Liemei Guo, Yang Wang, Jared S. Rosenblum, John S. Kovach, Mark R. Gilbert, Zhengping Zhuang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
car-t
lb-100
caix
pp2a
glioblastoma
Online Access:https://www.mdpi.com/2072-6694/12/1/139

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https://www.mdpi.com/2072-6694/12/1/139

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