The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins

The neurotoxic action of glutamic acid was first described by Lucas and Newhouse, who demonstrated neural degeneration in the inner layers of the neonatal mouse retina after systemic treatment with L-glutamate. Olney extended these findings by showing that neuronal degeneration affected other brain...

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Bibliographic Details
Main Authors: Joseph T. Coyle, Robert Schwarcz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00927/full