Regression analysis for constraining free parameters in electrophysiological models of cardiac cells.

A major challenge in computational biology is constraining free parameters in mathematical models. Adjusting a parameter to make a given model output more realistic sometimes has unexpected and undesirable effects on other model behaviors. Here, we extend a regression-based method for parameter sens...

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Bibliographic Details
Main Authors: Amrita X Sarkar, Eric A Sobie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2932676?pdf=render