DNA–protein cross-link repair: what do we know now?

Abstract When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common in cells, as it can arise from endogenous factors, such as aldehyde produced duri...

Full description

Bibliographic Details
Main Authors: Huimin Zhang, Yun Xiong, Junjie Chen
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cell & Bioscience
Subjects:
NER
HR
Online Access:https://doi.org/10.1186/s13578-019-0366-z