A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling

A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling

Abstract Background Triple-negative breast cancer (TNBC) represents a heterogeneous group of ER- and HER2-negative tumors with poor clinical outcome. We recently reported that Pten-loss cooperates with low expression of microRNA-145 to induce aggressive TNBC-like lesions in mice. To systematically i...

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Bibliographic Details
Main Authors: Dong-Yu Wang, Deena M. A. Gendoo, Yaacov Ben-David, James R. Woodgett, Eldad Zacksenhaus
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Breast Cancer Research
Subjects:
TNBC
Prognosis
microRNA
PTEN
RB1
TP53
Online Access:http://link.springer.com/article/10.1186/s13058-019-1098-z

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http://link.springer.com/article/10.1186/s13058-019-1098-z

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