Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

Abstract Background Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72 RE ) mutation – the most c...

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Bibliographic Details
Main Authors: Emma M. Perkins, Karen Burr, Poulomi Banerjee, Arpan R. Mehta, Owen Dando, Bhuvaneish T. Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M. Henstridge, Thomas H. Gillingwater, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran, Matthew R. Livesey
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Neurodegeneration
Subjects:
Synaptic
Network
C9ORF72
ALS
FTD
Repeat expansion
Online Access:https://doi.org/10.1186/s13024-021-00433-8

Internet

https://doi.org/10.1186/s13024-021-00433-8

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