Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis

Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis

Notochordal cells play a pivotal role in vertebral column patterning, contributing to the formation of the inner architecture of intervertebral discs (IVDs). Their disappearance during development has been associated with reduced repair capacity and IVD degeneration. Notochord cells can give rise to...

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Bibliographic Details
Main Authors: Paco López-Cuevas, Luke Deane, Yushi Yang, Chrissy L. Hammond, Erika Kague
Format: Article
Language:English
Published: The Company of Biologists 2021-03-01
Series:Disease Models & Mechanisms
Subjects:
chordoma
notochord
vertebral column
zebrafish intervertebral disc
inflammation
bone homeostasis
Online Access:http://dmm.biologists.org/content/14/3/dmm047001

Internet

http://dmm.biologists.org/content/14/3/dmm047001

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