PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment

PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment

Background and AimsPyruvate kinase M2 (PKM2) is an essential regulator of the Warburg effect, but its biological function promoting immune escape of hepatocellular carcinoma (HCC) is unclear.MethodsGEPIA web tool and immunohistochemistry (IHC) analysis were employed to evaluate the clinical relevanc...

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Bibliographic Details
Main Authors: Tian-En Li, Shun Wang, Xiao-Tian Shen, Ze Zhang, Mo Chen, Hao Wang, Ying Zhu, Da Xu, Bei-Yuan Hu, Ran Wei, Yan Zheng, Qiong-Zhu Dong, Lun-Xiu Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
pyruvate kinase M2
progression
immune escape
immunosuppressive microenvironment
PD-L1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.589997/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.589997/full

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