Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Abstract Amyloid β (Aβ) deposition in the brain is an early and invariable feature of Alzheimer’s disease (AD). The Aβ peptides are composed of about 40 amino acids and are generated from amyloid precursor proteins (APP), by β- and γ-secretases. The distribution of individual Aβ peptides in the brai...

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Bibliographic Details
Main Authors: Nobuto Kakuda, Tomohiro Miyasaka, Noriyuki Iwasaki, Takashi Nirasawa, Satoko Wada-Kakuda, Junko Takahashi-Fujigasaki, Shigeo Murayama, Yasuo Ihara, Masaya Ikegawa
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Acta Neuropathologica Communications
Subjects:
Amyloid β
Alzheimer’s disease
Cerebral amyloid angiopathy
Imaging mass spectrometry
C- and N-terminal variations of Aβ
Senile plaques
Online Access:http://link.springer.com/article/10.1186/s40478-017-0477-x

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http://link.springer.com/article/10.1186/s40478-017-0477-x

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