Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents

Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents

Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesized using condensation reactions of celecoxib with 2-aminoanthraquinone derivatives or 2-aminoanthraquinon with celecoxib derivatives. Celecoxib was reacted with different acid chlorides, 2-chloroethyl...

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Bibliographic Details
Main Authors: Maha S. Almutairi, Gehan H. Hegazy, Mogedda E. Haiba, Hamed I. Ali, Nagy M. Khalifa, Abd El-mohsen M. Soliman
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
antitumor
anthraquinone
celecoxib
HEPG2
docking
protein kinase activities
Online Access:http://www.mdpi.com/1422-0067/15/12/22580

Internet

http://www.mdpi.com/1422-0067/15/12/22580

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