Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants

Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants

Although both C-C chemokine receptor 5 (CCR5)- and CXC chemokine receptor 4 (CXCR4)-using HIV-1 strains cause AIDS, the emergence of CXCR4-utilizing variants is associated with an accelerated decline in CD4+ T cells. It remains uncertain if CXCR4-using viruses hasten disease or if these variants onl...

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Bibliographic Details
Main Authors: Nina Lin, Oscar A. Gonzalez, Ludy Registre, Carlos Becerril, Behzad Etemad, Hong Lu, Xueling Wu, Shahin Lockman, Myron Essex, Sikhulile Moyo, Daniel R. Kuritzkes, Manish Sagar
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:EBioMedicine
Subjects:
HIV
Envelope
Neutralization
Co-receptor
Evolution
Resistance
Tropism
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301852

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416301852

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