Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection.

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection.

Impaired immune responses in the elderly lead to reduced vaccine efficacy and increased susceptibility to viral infections. Although several groups have documented age-dependent defects in adaptive immune priming, the deficits that occur prior to antigen encounter remain largely unexplored. Herein,...

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Bibliographic Details
Main Authors: Justin M Richner, Grzegorz B Gmyrek, Jennifer Govero, Yizheng Tu, Gerritje J W van der Windt, Talibah U Metcalf, Elias K Haddad, Johannes Textor, Mark J Miller, Michael S Diamond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4512688?pdf=render

Internet

http://europepmc.org/articles/PMC4512688?pdf=render

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